Kamano ke efe lipakeng tsa ho tepella maikutlo nakong ea lilemo tse mahareng le Tau deposition?

Ho ea ka phuputso e ncha ea bafuputsi ba UT Health San Antonio le mekhatlo ea balekane ba eona, batho ba lilemong tse bohareng ba nang le matšoao a tepeletseng ba na le protheine e bitsoang APOE.Liphetoho ho epsilon 4 E ka ba le monyetla oa ho hlahisa tau buildup libakeng tsa boko tse laolang maikutlo le mohopolo.

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Liphuputso li phatlalalitsoe khatisong ea June 2021 ea Journal of Alzheimer's Disease.Thuto e ne e itšetlehile ka litlhahlobo tsa ho tepella maikutlong le litšoantšo tsa positron emission tomography (PET) tsa barupeluoa ba 201 ho Multigenerational Framingham Heart Study.Karolelano ea lilemo tsa ba nkang karolo e ne e le 53.

Monyetla oa ho fumana lefu lena lilemo tse mashome pele ho hlahlojoa

PET e atisa ho etsoa ho batho ba baholo ba baholo, kahoo Framingham STUDY ka PET lilemong tse bohareng e ikhetha, ho boletse Mitzi M. Gonzales, mongoli ea ka sehloohong oa thuto le neuropsychologist Setsing sa Glenn Biggs sa lefu la Alzheimer le Neurodegenerative Diseases, e leng karolo ea Setsi sa Bophelo sa Univesithi ea Texas ho SAN Antonio.

"Sena se re fa monyetla o thahasellisang oa ho ithuta batho ba lilemong tse bohareng le ho utloisisa lintlha tse ka 'nang tsa amahanngoa le ho bokella protheine ho batho ba tloaelehileng ba nang le tsebo," Dr. Gonzales o itse."Haeba batho bana ba tsoela pele ho ba le 'dementia", phuputso ena e tla senola menyetla eo lilemo tse mashome pele ho hlahlojoa."

Ha e amane le beta-amyloid

Beta-amyloid (Aβ) le Tau ke liprotheine tse bokellanang ka bokong ba batho ba nang le lefu la Alzheimer's 'me hangata li eketseha butle le lilemo.Phuputso ha e fumane kamano pakeng tsa matšoao a tepeletseng maikutlo le khatello ea maikutlo le beta-amyloid.E ne e amahanngoa le Tau feela, 'me ke feela bajari ba phetoho ea APOE ε4.Hoo e ka bang kotara ea bakuli ba 201 (47) ba ne ba nkile lefutso la ε4 hobane bonyane ba ne ba e-na le ε4 allele.

Ho nka kopi e le 'ngoe ea lefutso la APOEε4 ho eketsa kotsi ea lefu la alzheimer ka makhetlo a mabeli ho isa ho a mararo, empa batho ba bang ba nang le mefuta e fapaneng ea lefutso ba ka phela ho fihlela lilemong tsa bo-80 kapa 90 ntle le ho tšoaroa ke lefu lena."Ke habohlokoa ho hopola hore hobane feela motho a tsejoa hore o jere APOE ε4 ha ho bolele hore o tla ba le 'dementia' nakong e tlang," Dr. Gonzales o itse.Ho bolela feela hore mathata a phahame. "

Matšoao a ho tepella maikutlo (ho tepella maikutlo haeba matšoao a le matla ka ho lekaneng ho finyella moeli ona oa ho hlahloba) a ile a hlahlojoa nakong ea litšoantšo tsa PET le lilemo tse robeli pele ho sebelisoa Epidemiological Research Center Depression Scale.Matšoao a ho tepella maikutlong le kamano pakeng tsa ho tepella maikutlong le liphello tsa PET ka linako tse peli li ile tsa hlahlojoa, tsa lokisoa bakeng sa lilemo le tekano.

Litsi tsa maikutlo le tsa kelello

Phuputso e bontšitse kamano pakeng tsa matšoao a tepeletseng le ho eketseha ha tau libakeng tse peli tsa boko, entorhinal cortex le amygdala."Mekhatlo ena ha e bolele hore ho bokella tau ho baka matšoao a tepeletseng maikutlo kapa ka tsela e fapaneng," ho boletse Dr. Gonzales."Re hlokometse feela lintho tsena tse peli ho bajari ba ε4."

O hlokometse hore entorhinal cortex e bohlokoa bakeng sa ho kopanya mohopolo 'me e atisa ho ba sebaka seo ho kenngoa ha protheine ho etsahala kapele.Ho sa le joalo, ho nahanoa hore amygdala ke setsi sa maikutlo sa boko.

"Lithuto tsa longitudinal lia hlokahala ho tsoela pele ho utloisisa se etsahalang, empa hoa thahasellisa ho nahana ka liphello tsa kliniki tsa seo re se fumaneng mabapi le taolo ea kelello le maikutlo," ho boletse Dr. Gonzales.


Nako ea poso: 26-08-21